- [Resource Hub](/)
- [Resource](/?resource-type=product-documentation#library)
- Orion LE

# Orion LE Spatial Proteomics System

Orion LE is the entry configuration of the Orion spatial proteomics platform — 14-channel, whole-slide multiplex imaging for targeted panels on a field-upgradeable instrument that grows with your program.

Orion LE brings the Orion platform's high-speed immunofluorescence imaging to targeted panels: 14 channels per round at sub-micron resolution, across the whole slide. When a study needs more markers, the lab adds rounds; multi-round acquisition extends the plex for higher-plex work without moving to another instrument.

The configuration is designed to scale. It holds 2 slides and manages data through OMERO Plus for multi-user teams. Because the instrument is field-upgradeable, a lab can start with focused panels and grow into multiple projects and large cohort studies as the work expands.

Read or download to see:

- 14 imaging channels per round. Orion LE records 14-channel multiplex immunofluorescence in each high-speed imaging round, with multi-round capability to extend the plex for higher-plex studies.

- Sub-micron, whole-slide resolution. A 20X 0.8 NA objective and a 2048 × 2048 sCMOS camera (6.5 µm pixels, 95% QE, 1.0-electron read noise) resolve entire slides at sub-micron detail, paired with a 4X 0.13 NA objective.

- Field-upgradeable, 2-slide instrument. Orion LE holds 2 slides and scans at 4 minutes per cm² per channel within a 21 × 22 × 23.5 in footprint. The design is field-upgradeable, so the system grows with the program instead of being replaced.

- OMERO Plus data management for shared teams. Scans are written as 16-bit OME-TIFF to a 12 TB workstation on 10-gigabit Ethernet, and OMERO Plus gives multi-user groups one place to review and annotate the images.

[Download spec sheet](https://cdn.sanity.io/files/s3p6uqps/production/d74a399efb27fd33757c3d57d7a4bd067641d3d6.pdf)

Your browser doesn't support embedded PDFs.
[Download the Orion LE spec sheet](https://cdn.sanity.io/files/s3p6uqps/production/d74a399efb27fd33757c3d57d7a4bd067641d3d6.pdf) to view it.

[Back to all resources](/#library)
## Related resources
[Article](https://www.selectscience.net/article/advanced-spatial-biology-sheds-new-light-on-therapeutic-research) Orion SelectScience
### Advanced spatial biology sheds new light on therapeutic research
[Read Article](https://www.selectscience.net/article/advanced-spatial-biology-sheds-new-light-on-therapeutic-research) [Article](https://www.selectscience.net/editorial-articles/bringing-spatial-biology-to-the-clinic-a-new-lens-on-cancer-biology/?&artID=58147) Orion SelectScience
### Bringing spatial biology to the clinic: “A new lens on cancer biology”
[Read Article](https://www.selectscience.net/editorial-articles/bringing-spatial-biology-to-the-clinic-a-new-lens-on-cancer-biology/?&artID=58147) [Article](https://www.selectscience.net/article/how-to-unlock-the-complexity-of-tumor-microenvironments) Orion SelectScience
### How to unlock the complexity of tumor microenvironments
[Read Article](https://www.selectscience.net/article/how-to-unlock-the-complexity-of-tumor-microenvironments) [Brochure](https://go.pardot.com/l/455452/2020-07-15/8p7453/455452/1606951069teslfZQe/BR21_101_Orion_Brochure_201202.pdf) Orion
### Orion Spatial Proteomics Platform
[View Brochure](https://go.pardot.com/l/455452/2020-07-15/8p7453/455452/1606951069teslfZQe/BR21_101_Orion_Brochure_201202.pdf) [Spec Sheet](https://pardot.rarecyte.com/l/455452/2026-02-24/965v3w/455452/1771949067AeuR6syb/Orion_HT_spec_sheet.pdf) Orion
### Orion HT
[View Spec Sheet](https://pardot.rarecyte.com/l/455452/2026-02-24/965v3w/455452/1771949067AeuR6syb/Orion_HT_spec_sheet.pdf) [Spec Sheet](https://go.pardot.com/l/455452/2020-07-15/8p742r/455452/1607104572nfrlJouR/DF_24_101_201203_Orion_Datafile.pdf) Orion
### Orion
[View Spec Sheet](https://go.pardot.com/l/455452/2020-07-15/8p742r/455452/1607104572nfrlJouR/DF_24_101_201203_Orion_Datafile.pdf) [Research Spotlight](/resources/spatial-profiling-immune-correlates-mss-crc/) Orion 2026
### Spatial Profiling Uncovers Immune Correlates of Durable Response in Phase 1/2 MSS Colorectal Cancer Trial
[Read Spotlight](/resources/spatial-profiling-immune-correlates-mss-crc/) [Publication](/resources/copanlisib-nivolumab-microsatellite-stable-colorectal/) Orion Nature Communications 2026
### Copanlisib in combination with nivolumab for microsatellite stable colorectal cancer: a phase 1/2 trial
[Read More](/resources/copanlisib-nivolumab-microsatellite-stable-colorectal/) [Publication](https://doi.org/10.1158/2159-8290.CD-26-0171) Orion Cancer Discovery 2026
### Spatial Integration of Protein and Chromosomal States Reveals Early Copy-Number Changes and Genotype-Associated Immune Neighborhoods in Serous Ovarian Cancer Evolution
[View Publication](https://doi.org/10.1158/2159-8290.CD-26-0171) [Publication](https://www.nature.com/articles/s41467-026-74933-w) Orion Nature Communications 2026
### Multiple human transgenes prolong survival of triple-carbohydrate knockout porcine kidney xenografts in nonhuman primates
[View Publication](https://www.nature.com/articles/s41467-026-74933-w) [Video](https://www.youtube.com/watch?v=KOiToZIGN0g) Orion 2026
### Dr. Tanjina Kader on mapping spatial proteomics and chromosomal changes on the same tissue section
[Watch Video](https://www.youtube.com/watch?v=KOiToZIGN0g) [Blog](/resources/multiplex-if-choosing-right-technology/) Orion 2026
### Understanding Multiplex Immunofluorescence: Choosing the Right Technology for Discovery, Biomarker Development, and Clinical Research
[Read Blog](/resources/multiplex-if-choosing-right-technology/)