- [Resource Hub](/)
- [Resource](/?resource-type=product-documentation#library)
- Orion

# Orion Spatial Proteomics Instrument

Orion images 20 channels per round across a whole slide at sub-micron resolution, giving spatial-biology researchers high-plex immunofluorescence, IHC, and same-section H&E from one automated instrument.

Orion runs high-speed, whole-slide imaging at sub-micron resolution and generates quantitative image analysis in parallel with the scan. You skip the separate analysis pass, since the data comes off the instrument ready to quantify. Integrated brightfield optics capture H&E on the same section as the immunofluorescence panel, and multi-round imaging takes the base 20-channel-per-round configuration to higher plex when a study calls for it.

OMERO Plus data management supports multi-user collaboration across 28 TB of onboard scan storage, and the whole system sits on a benchtop — sized for shared facilities and large cohort work.

Read or download to see:

- 20 channels per round at sub-micron, whole-slide resolution. High-speed scanning runs at 4 minutes per cm² per channel through a 20X 0.8 NA objective, across 402–808 nm excitation and a 450–874 nm emission range.

- Same-section H&E and quantitative analysis, built in. Integrated brightfield optics image H&E on the same section as the immunofluorescence panel, and quantitative image analysis runs in parallel with the scan, written to 16-bit OME-TIFF.

- Multi-round capability for higher-plex panels. The base configuration images 20 channels per round and extends through additional rounds; a 2048 × 2048 sCMOS camera at 6.5 µm pixels, 95% QE, and 1.0 electron read noise records every channel.

- Built for shared, cohort-scale labs. OMERO Plus data management, 28 TB of scan storage, 10 GB ethernet, and a two-slide stage run from a 21 × 22 × 23.5 in (53.4 × 56 × 60 cm) benchtop footprint on a Windows 10 Enterprise workstation.

[Download spec sheet](https://cdn.sanity.io/files/s3p6uqps/production/2768a152d3f3150bb94845d613e81122d1743999.pdf)

Your browser doesn't support embedded PDFs.
[Download the Orion spec sheet](https://cdn.sanity.io/files/s3p6uqps/production/2768a152d3f3150bb94845d613e81122d1743999.pdf) to view it.

[Back to all resources](/#library)
## Related resources
[Article](https://www.selectscience.net/article/advanced-spatial-biology-sheds-new-light-on-therapeutic-research) Orion SelectScience
### Advanced spatial biology sheds new light on therapeutic research
[Read Article](https://www.selectscience.net/article/advanced-spatial-biology-sheds-new-light-on-therapeutic-research) [Article](https://www.selectscience.net/editorial-articles/bringing-spatial-biology-to-the-clinic-a-new-lens-on-cancer-biology/?&artID=58147) Orion SelectScience
### Bringing spatial biology to the clinic: “A new lens on cancer biology”
[Read Article](https://www.selectscience.net/editorial-articles/bringing-spatial-biology-to-the-clinic-a-new-lens-on-cancer-biology/?&artID=58147) [Article](https://www.selectscience.net/article/how-to-unlock-the-complexity-of-tumor-microenvironments) Orion SelectScience
### How to unlock the complexity of tumor microenvironments
[Read Article](https://www.selectscience.net/article/how-to-unlock-the-complexity-of-tumor-microenvironments) [Brochure](https://go.pardot.com/l/455452/2020-07-15/8p7453/455452/1606951069teslfZQe/BR21_101_Orion_Brochure_201202.pdf) Orion
### Orion Spatial Proteomics Platform
[View Brochure](https://go.pardot.com/l/455452/2020-07-15/8p7453/455452/1606951069teslfZQe/BR21_101_Orion_Brochure_201202.pdf) [Spec Sheet](https://pardot.rarecyte.com/l/455452/2026-02-24/965v3w/455452/1771949067AeuR6syb/Orion_HT_spec_sheet.pdf) Orion
### Orion HT
[View Spec Sheet](https://pardot.rarecyte.com/l/455452/2026-02-24/965v3w/455452/1771949067AeuR6syb/Orion_HT_spec_sheet.pdf) [Spec Sheet](https://pardot.rarecyte.com/l/455452/2025-10-31/961nyb/455452/1761933957WEJWJyeN/2025.07.14___SS___Orion__LE_.pdf) Orion
### Orion LE
[View Spec Sheet](https://pardot.rarecyte.com/l/455452/2025-10-31/961nyb/455452/1761933957WEJWJyeN/2025.07.14___SS___Orion__LE_.pdf) [Research Spotlight](/resources/spatial-profiling-immune-correlates-mss-crc/) Orion 2026
### Spatial Profiling Uncovers Immune Correlates of Durable Response in Phase 1/2 MSS Colorectal Cancer Trial
[Read Spotlight](/resources/spatial-profiling-immune-correlates-mss-crc/) [Publication](/resources/copanlisib-nivolumab-microsatellite-stable-colorectal/) Orion Nature Communications 2026
### Copanlisib in combination with nivolumab for microsatellite stable colorectal cancer: a phase 1/2 trial
[Read More](/resources/copanlisib-nivolumab-microsatellite-stable-colorectal/) [Publication](https://doi.org/10.1158/2159-8290.CD-26-0171) Orion Cancer Discovery 2026
### Spatial Integration of Protein and Chromosomal States Reveals Early Copy-Number Changes and Genotype-Associated Immune Neighborhoods in Serous Ovarian Cancer Evolution
[View Publication](https://doi.org/10.1158/2159-8290.CD-26-0171) [Publication](https://www.nature.com/articles/s41467-026-74933-w) Orion Nature Communications 2026
### Multiple human transgenes prolong survival of triple-carbohydrate knockout porcine kidney xenografts in nonhuman primates
[View Publication](https://www.nature.com/articles/s41467-026-74933-w) [Video](https://www.youtube.com/watch?v=KOiToZIGN0g) Orion 2026
### Dr. Tanjina Kader on mapping spatial proteomics and chromosomal changes on the same tissue section
[Watch Video](https://www.youtube.com/watch?v=KOiToZIGN0g) [Blog](/resources/multiplex-if-choosing-right-technology/) Orion 2026
### Understanding Multiplex Immunofluorescence: Choosing the Right Technology for Discovery, Biomarker Development, and Clinical Research
[Read Blog](/resources/multiplex-if-choosing-right-technology/)