- [Resource Hub](/)
- [Resource](/?resource-type=webinar#library)
- Spatial Biology: Applying Cellular Phenotyping in Health and Disease

# Spatial Biology: Applying Cellular Phenotyping in Health and Disease

How spatial context at the subcellular level shapes the study of cells in health and disease — and how Orion™ technology sets out to resolve the challenges of reading it.

In this webinar, Mickael Meyrand, a Field Application Scientist at RareCyte, Inc., looks at spatial biology and the cellular phenotyping of tissue in health and disease. His starting point is the tissue itself: a mix of heterogeneous cell types, each with its own functions and functional states, whose spatial organization can shape health status. Cellular phenotyping is the work of telling those cell types and states apart, and reading where they sit within the tissue.

Understanding that spatial context at the subcellular level is often difficult. Meyrand frames the obstacles as imaging resolution, throughput, and the assessment of multiple targets at the same time. Each of these limits how fully the spatial organization of cells in a tissue can be read.

Against that backdrop, the session presents Orion™ technology as resolving these challenges — the imaging resolution, throughput, and simultaneous target assessment that reading spatial context at the subcellular level requires. It is an applied look at studying cells, and the way they are organized in space, across health and disease.

[Back to all resources](/#library)
## Related resources
[Article](https://www.selectscience.net/article/advanced-spatial-biology-sheds-new-light-on-therapeutic-research) Orion SelectScience
### Advanced spatial biology sheds new light on therapeutic research
[Read Article](https://www.selectscience.net/article/advanced-spatial-biology-sheds-new-light-on-therapeutic-research) [Article](https://www.selectscience.net/editorial-articles/bringing-spatial-biology-to-the-clinic-a-new-lens-on-cancer-biology/?&artID=58147) Orion SelectScience
### Bringing spatial biology to the clinic: “A new lens on cancer biology”
[Read Article](https://www.selectscience.net/editorial-articles/bringing-spatial-biology-to-the-clinic-a-new-lens-on-cancer-biology/?&artID=58147) [Article](https://www.selectscience.net/article/how-to-unlock-the-complexity-of-tumor-microenvironments) Orion SelectScience
### How to unlock the complexity of tumor microenvironments
[Read Article](https://www.selectscience.net/article/how-to-unlock-the-complexity-of-tumor-microenvironments) [Brochure](https://go.pardot.com/l/455452/2020-07-15/8p7453/455452/1606951069teslfZQe/BR21_101_Orion_Brochure_201202.pdf) Orion
### Orion Spatial Proteomics Platform
[View Brochure](https://go.pardot.com/l/455452/2020-07-15/8p7453/455452/1606951069teslfZQe/BR21_101_Orion_Brochure_201202.pdf) [Spec Sheet](https://pardot.rarecyte.com/l/455452/2026-02-24/965v3w/455452/1771949067AeuR6syb/Orion_HT_spec_sheet.pdf) Orion
### Orion HT
[View Spec Sheet](https://pardot.rarecyte.com/l/455452/2026-02-24/965v3w/455452/1771949067AeuR6syb/Orion_HT_spec_sheet.pdf) [Spec Sheet](https://pardot.rarecyte.com/l/455452/2025-10-31/961nyb/455452/1761933957WEJWJyeN/2025.07.14___SS___Orion__LE_.pdf) Orion
### Orion LE
[View Spec Sheet](https://pardot.rarecyte.com/l/455452/2025-10-31/961nyb/455452/1761933957WEJWJyeN/2025.07.14___SS___Orion__LE_.pdf) [Spec Sheet](https://go.pardot.com/l/455452/2020-07-15/8p742r/455452/1607104572nfrlJouR/DF_24_101_201203_Orion_Datafile.pdf) Orion
### Orion
[View Spec Sheet](https://go.pardot.com/l/455452/2020-07-15/8p742r/455452/1607104572nfrlJouR/DF_24_101_201203_Orion_Datafile.pdf) [Research Spotlight](/resources/spatial-profiling-immune-correlates-mss-crc/) Orion 2026
### Spatial Profiling Uncovers Immune Correlates of Durable Response in Phase 1/2 MSS Colorectal Cancer Trial
[Read Spotlight](/resources/spatial-profiling-immune-correlates-mss-crc/) [Publication](/resources/copanlisib-nivolumab-microsatellite-stable-colorectal/) Orion Nature Communications 2026
### Copanlisib in combination with nivolumab for microsatellite stable colorectal cancer: a phase 1/2 trial
[Read More](/resources/copanlisib-nivolumab-microsatellite-stable-colorectal/) [Publication](https://doi.org/10.1158/2159-8290.CD-26-0171) Orion Cancer Discovery 2026
### Spatial Integration of Protein and Chromosomal States Reveals Early Copy-Number Changes and Genotype-Associated Immune Neighborhoods in Serous Ovarian Cancer Evolution
[View Publication](https://doi.org/10.1158/2159-8290.CD-26-0171) [Publication](https://www.nature.com/articles/s41467-026-74933-w) Orion Nature Communications 2026
### Multiple human transgenes prolong survival of triple-carbohydrate knockout porcine kidney xenografts in nonhuman primates
[View Publication](https://www.nature.com/articles/s41467-026-74933-w) [Video](https://www.youtube.com/watch?v=KOiToZIGN0g) Orion 2026
### Dr. Tanjina Kader on mapping spatial proteomics and chromosomal changes on the same tissue section
[Watch Video](https://www.youtube.com/watch?v=KOiToZIGN0g)